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CTT function. Known functional roles of the CTT are presented schematically. (1) The CTT has been demonstrated to influence endocytosis of Env from the cell surface through interactions with AP1 and AP2. (2) Through interactions with Gag, the CTT plays a role in incorporation of Env into budding virions. (3) The interaction between Gag and the CTT may play a role in virion maturation.
