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Proposed topology models for HIV gp41 CTT. The two predominant CTT topology models are presented. (Left) Traditional CTT topology model, with completely intracytoplasmic CTT. (Right) model proposed by Hollier & Dimmock (2005), with the KE (yellow) externally localized. Transmembrane domains are as presented in detail in Fig. 5. Red boxes indicate functional endocytic sequences.
