Table 1. List of the published antibodies binding to the gp41 CTT.
na, Not available.
Name of the antibody | Targeted region | Epitope sequence | Epitope characteristics | Species/clonality | Antibody characteristics | References |
Chessie 8 | KE | PDRPEG | Conformational | Murine IgG | Non-neutralizing binds to HIV-infected cells | Abacioglu et al. (1994) |
SAR1 | KE | GERDRDR | Conformational | Murine IgG | PAN-neutralizing binds to HIV-infected cells and most virions, no binding to intact NL4.3 virions | Reading et al. (2003), Heap et al. (2005), Steckbeck et al. (2010) |
EPES (epitope-purified ERDRD specific) | KE | ERDRD | Conformational | Murine polyclonal | Neutralizing binds to HIV-infected cells and virions | Buratti et al. (1998), Cleveland et al. (2000b, 2003) |
anti-LLP2 | LLP2 | na | na | Rabbit polyclonal IgG | na | Lu et al. (2008) |
1575 | KE | IEEE | Linear immunodominant | Murine monoclonal | Non-neutralizing binds to HIV-infected cells and virions | Buratti et al. (1996, 1997, 1998), Cleveland et al. (2000a), Evans et al. (1989), Heap et al. (2005), Vella et al. (1993) |
1577 | KE | ERDRD | Conformational | Murine monoclonal IgG | Non-neutralizing binding to HIV-infected cells and virions (Dimmock), no binding to intact virions (Steckbeck), epitope binding inhibited by mAb1575 | Beaumont et al. (2000), Buratti et al. (1996, 1998), Chomont et al. (2008), Cleveland et al. (2000a, 2003), Evans et al. (1989), Holl et al. (2006), Steckbeck et al. (2010), Vella et al. (1993) |
1583 | KE | ERDRD | Conformational | Murine monoclonal IgG | Non-neutralizing binds to virions | Evans et al. (1989), Buratti et al. (1996, 1998), Vella et al. (1993), Cleveland et al. (2003), Heap et al. (2005) |