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In the crystal structure [55] (Protein Data Bank entry 1JSU), the kinase inhibitory domain of p27Kip1 (KID, in green) is observed to be partly helical and interact with both the kinase and the cyclin. When it is free in solution, KID is mostly disordered, but some of the helical structure is already present [54], making conformer selection a plausible alternative to induced fit as an explanation of the rapid association with the cyclin.
