Table 1. Comparison of IC50 and Ki values of standard CDK inhibitors.
Results are expressed as mean values±sd of at least three independent experiments (n = 3–6). See also Fig. 2(b).
| CDK inhibitor | IC50 (nM) | Ki (nM) | ||||
| EtCRK2/XlRINGO | EtCRK2/EtCYC3a | HsCDK2/HsCYCA | EtCRK2/XlRINGO | EtCRK2/EtCYC3a | HsCDK2/HsCYCA | |
| Staurosporine | 90±10 | 190±90 | 3±1 | 20±10 | 530±200 | 1±0 |
| Indirubin-5′-sulfonic acid | 670±180 | 940±310 | 230±110 | 170±30 | 240±100 | 80±10 |
| Purvalanol A | 800±110 | 1030±180 | 140±40 | 80±10 | 360±130 | 40±1 |
| Alsterpaullone | 220±60 | 640±340 | 160±80 | 70±2 | 210±40 | 60±0 |
| Flavopiridole | 40±10 | 260±70 | 50±10 | 10±3 | 260±20 | 20±4 |
| 10-Z-Hymendialdisine | 440±80 | 930±40 | 120±20 | 50±20 | 190±10 | 30±1 |