FIG. 3.

Profiling of bioactive molecules and quantification of wound healing-related growth factors in human placenta and placenta-derived ECM. (A) Cytokines and (B) growth factors were arrayed on glass chip arrays containing 80 different cytokine antibodies and detected by a laser scanner using the Cy3 channel. Bioactive molecules were normalized to positive control. (C) Growth factors that are known to stimulate wound repair were quantified via ELISA. Data are shown as mean±standard deviation (n=5) with significance at *p<0.05 between the human placenta and ECM. BDNF, brain-derived neurotrophic factor; BLC, B-lymphocyte chemoattractant; Ckβ8, chemokine beta 8; EGF, epidermal growth factor; FGF-2, fibroblast growth factor-2; GCP, granulocyte chemotactic protein; GDNF, glial-derived neurotrophic factor; SDF, stromal cell-derived factor; GRO, growth-regulated protein; HGF, hepatocyte growth factor; IGF-1, insulin-like growth factor-1; IGFBP, IGF binding proteins; LIF, leukemia inhibitory factor; IL, interleukin; Lor, Loricrin; MIF, macrophage migration inhibitory factor; MIP, macrophage inflammatory protein; NAP, neutrophil-activating peptide; NT, neurotrophin; PARC, pulmonary and activation-regulated chemokine; PDGF, platelet-derived growth factor; PIGF, placenta growth factor; RANTES, regulated upon activation, normal T-cell expressed, and secreted; SCF, stem cell factor; TIMP, tissue inhibitor of metalloproteinase; TGF-β, transforming growth factor-β; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.