FIGURE 6.

Effect of biotechnological heparins on the interaction of p17 to its receptors. K5 derivatives were evaluated for their capacity to inhibit the interaction of p17 with heparin (A) or CXCR1 (B) immobilized to a sensorchip. The responses were plotted as percentage of the binding of p17 measured in the absence of any free GAG. Each point is the mean ± S.E. of three separate determinations. A, inset, the potency (ID₅₀) of the various GAGs in inhibiting the binding of p17 to immobilized heparin were plotted against their SO₃⁻/COO⁻ ratio. The correlation coefficient of the linear regression was equal to −0.96.