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. 2012 Nov 16;288(2):1171–1183. doi: 10.1074/jbc.M112.386722

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Diagram showing the possible mechanism of the regulation of actin polymerization and cell migration by SKAP2. Left, WAVE2 is recruited to cortactin at the cell membrane, polymerizes actin through Arp2/3 complex, and cell migration occurs. Middle, SKAP2 interferes with the association between WAVE2 and cortactin, and inhibits actin polymerization, which suppresses cell migration and tumor invasion. Right, SKAP2-phosphorylation by SFKs attenuates its inhibitory effect on WAVE2-cortactin interaction, cell migration and invasion.