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. 2012 Nov 15;288(2):1295–1306. doi: 10.1074/jbc.M112.409250

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FIGURE 3. — L803-mts restores impaired lysosomal acidification in the 5XFAD mouse brain. A, levels of precursor CatD (∼46–52 kDa) and the proteolytic product mCatD (∼32 kDa) in brain samples from WT and L803-mts-treated or nontreated 5XFAD mice as determined by immunoblot analysis. β-Actin levels are also shown. B, glycosylated (120 kDa) and nonglycosylated (100 kDa) v-ATPase V0a1 in brain samples from WT and L803-mts-treated or nontreated 5XFAD mice as determined by immunoblot analysis. Densitometry analysis of indicated proteins is shown on the right of each panel. The results are the means ± S.E. of five or six animals. *, p < 0.05; **, p < 0.005.