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Hypoxia-induced HMGB1 release leads to inhibition of HPAEC migration via TLR4. VEGF-stimulated cell migration was assessed in HPAECs exposed to (A) hypoxia (1% O2), (B) αHMGB1-neutralizing antibody (10 μg/ml) or IgG control antibody, (C) hypoxia when transfected with siRNA against TLR4 (25 nm) or control siRNA (25 nm). Data represent the mean ± S.E. (error bars) of three to four independent experiments. Analysis of variance; *, p < 0.05.
