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Differential gene induction by HMGB1 in HPAECs versus HUVECs. A and B, HPAECs (A) and HUVECs (B) were stimulated with HMGB1 (1 μg/ml) for 4 h and then assessed for the induction of ISG20, IFNβ, or iNOS mRNA by RT-PCR. C and D, the relative expression of each gene is quantified in the histograms and normalized to GAPDH mRNA expression. Data represent the mean ± S.E. (error bars) of three independent experiments. Analysis of variance; *, p < 0.05 versus unstimulated control.
