TABLE 2.
Summary of binding kinetics for different peptide-antibody fusion proteins to human IL17A
| Peptide-Antibodies | ka | kd | KD |
|---|---|---|---|
| m−1 s−1 | s−1 | nm | |
| Q-G-HC | 2.0 ± 0.5 × 104 | 1.0 ± 0.2 × 10−3 | 51 ± 6 |
| Q-G6-HC | 1.8 ± 0.5 × 104 | 9.2 ± 0.9 × 10−4 | 50 ± 10 |
| Q-GSE12-HC | 2.1 ± 0.8 × 104 | 1.5 ± 0.3 × 10−3 | 70 ± 40 |
| Q-G-LC | 3.1 ± 0.6 × 104 | 7 ± 2 × 10−4 | 23 ± 6 |
| Q-G6-LC | 3 ± 1 × 104 | 1.1 ± 0.2 × 10−3 | 32 ± 9 |
| Q-GSE12-LC | 2.8 ± 0.9 × 104 | 1.4 ± 0.1 × 10−3 | 50 ± 10 |
| Q-G-Tetravalent | 2.0 ± 0.8 × 104 | 1.0 ± 0.1 × 10−3 | 50 ± 20 |
| Q-G6-Tetravalent | 1.3 ± 0.5 × 104 | 1.0 ± 0.1 × 10−3 | 80 ± 20 |
| Q-GSE12-Tetravalent | 2 ± 1 × 104 | 1.5 ± 0.3 × 10−3 | 80 ± 70 |
| Q-GSE21-Tetravalent | 4 ± 2 × 104 | 1.9 ± 0.8 × 10−3 | 50 ± 20 |