FIGURE 5.

Changes in plasma Aβ profile in healthy human volunteers after a single oral administration of the GSI Semagacestat. Plasma Aβ₄₀ levels were measured at three Semagacestat concentrations: 40 mg (■), 100 mg (●), and 140 mg (♦). The model quantitative describes Aβ₄₀ levels at the three doses (40 mg, solid line; 100 mg, dashed line; and 140 mg, dot dashed line). The model also describes the profile of Semagacestat in plasma shown in the inset. For model residual error, residual errors = 11%. F test statistics, F = 10.7, p value < 10⁻⁵. The residual plot is shown in supplemental Fig. S3. Error bars indicate S.E.