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IC50 for block of nAChR subtypes by α-CTx TxIB and TxIB(G)
| Peptide | Subtype | IC50a |
|---|---|---|
| nm | ||
| TxIB | α6/α3β2β3 | 28.4 (18.6–43.4) |
| TxIB(G) | α6/α3β2β3 | 247 (186–329) |
| TxIB TxIB(G) | α6/α3β4 | >10,000b |
| α7 | >10,000b | |
| α9α10 | >10,000b | |
| Mα1β1δϵ | >10,000b | |
| α2β2 | >10,000b | |
| α2β4 | >10,000b | |
| α3β2 | >10,000b | |
| α3β4 | >10,000b | |
| α4β2 | >10,000b | |
| α4β4 | >10,000b |
a Numbers in parentheses are 95% confidence intervals.
b Less than 50% block at 10−5 m. All receptors are rat except for α1β1δϵ, which is mouse.
