FIGURE 3.

Rigid-body docking of the RyR1 fragment model into cryo-EM maps of RyR1. A, pseudo-atomic model of RyR1 fragment (residues 850–1,056, shown as blue ribbons) docked into the cryo-EM map of a closed conformation RyR1 (EMDB 1606, shown as blue mesh). B, top ranked docking solutions of RyR1 fragment in the closed state RyR1, solutions ranked 3–6 (blue bars) are the four positions shown as blue ribbons in A. C, RyR1 fragment pseudo-atomic model (shown as red ribbons) docked into the cryo-EM map of the open conformation of RyR1 (EMDB 1607, shown as red mesh). D, top ranked docking solutions of RyR1 fragment in the open state RyR1, solutions ranked 1–4 (red bars) are the positions shown as red ribbons in C.