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. 2012 Nov 14;288(2):915–926. doi: 10.1074/jbc.M112.411363

FIGURE 6.

FIGURE 6.

Mitophagy is impaired in Parkin-deficient hearts. A and B, induction of autophagy in the border zone (A) and remote zone (B) 4 h after MI. Western blots and quantitation analyses for LC3II/I levels in the border zone at base-line (Con) in the ventricle and in the border zone 4 h after MI are shown. Mean ± S.E. (*, p < 0.05 versus control, n = 8) AU, arbitrary units; n.s., not significant. C, Western blots for Parkin and LC3 in the mitochondrial fractions of the border zones of WT and Parkin−/− mice 4 h after MI. D, Western blots for ubiquitinated proteins in the cytosolic and mitochondrial fractions of the border zones of WT and Parkin−/− mice 4 h after MI. E, Western blots for Parkin and LC3 in the mitochondrial fractions of the remote zones of WT and Parkin−/− mice 4 h after MI. F, Western blots for ubiquitinated proteins in the cytosolic and mitochondrial fractions of the remote zones of WT and Parkin−/− mice 4 h after MI.