Figure 4.

Lewy bodies in dopaminergic neurons from the substantia nigra pars compacta. In humans suffering from Parkinson’s disease, dopaminergic neurons accumulate intracytoplasmatic aggregates of misfolded α-synuclein. These aggregates often adopt a circular shape and form the so-called Lewy bodies, which represent the pathological hallmark of this disease. Dual immunofluorescent detection of tyrosine hydroxylase (red channel) and α-synuclein (green channel), identifying two dopaminergic neurons from a PD patient, one of them showing a typical intracytoplasmic Lewy body.