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Schematic summary of the original basal ganglia model. The motor circuit is composed of a corticostriatal (putaminal) projection, two major striatofugal projection systems giving rise to the direct and indirect pathways, and the efferent pallido–thalamo–cortical projections to close the motor loop. The thickness of arrows represents the functional state of a given circuit. Thicker arrows illustrate hyperactive pathways, whereas thinner arrows represent hypoactive circuits.
