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. 2013 Feb;19(2):129–140. doi: 10.1261/rna.034777.112

FIGURE 6.

FIGURE 6.

IRP-1 interactions with APP and α-synuclein mRNA. (A) Interaction map of IRP-1 with APP (secondary structure elements are displayed at the “protein residue index” axis; blue areas indicate experimentally validated interactions). RNA-interaction profiles for IRP-1 associations with (B) APP and (C) α-synuclein mRNA (blue lines indicate experimentally identified binding regions) (Supplemental Table 1). (D) Interaction strength for IRP-1 domain 4 region (amino acids 661–889) and putative IRE fragment in α-synuclein transcript (nucleotides 190–252) (Supplemental Table 1).