Figure 1.

VEGF gene polymorphisms. The VEGF gene and surrounding sequence are outlined. Each + represents a polymorphic site. The position of the full-length transcript, exons, and longest splice form are diagrammed. The position of commonly assessed polymorphisms according to both of the commonly used numbering schemes (from the transcription start point “mRNA,” and from the translation start point “ATG”) are indicated. The three major regions of linkage disequilibrium are shown, together with common haplotypes. The haplotype numbering schemes of Stevens (s) (Stevens et al. 2003), Awata (a) (Awata et al. 2005), Garcia-Closas (g) (Garcia-Closas et al. 2007), and McKay (m) (McKay et al. 2009) are indicated, as well as the frequency of the haplotypes in the indicated control populations. Shaded genotypes indicate a difference with the chimpanzee or orangutan genome, suggesting that the shaded allele is the derived allele. The position of the 936C > T polymorphism in the 3′ UTR is also indicated.