Table 2.
Rodent angiogenic response QTLs
| QTL | Location | Effect of paternal allele | Cross | Reference |
|---|---|---|---|---|
| Edpm5 | Rat Chr 5M | Resistance to estrogen-induced pituitary tumor angiogenesis | Fisher 344 x Brown Norway | Pandey et al. 2004 |
| Skts9 | Chr 16P | Skin tumor resistance | NIH/Ola x M. spretus | Nagase et al. 1999 |
| Mmtg1 | Chr 4P | Increased tumor burden | I/LnJ x FVB/N-TgN(MMTV-PyVT)634Mu1 | Le Voyer et al. 2001 |
| Mmtg2 | Chr 4M | Increased tumor burden | I/LnJ x FVB/N-TgN(MMTV-PyVT)634Mu1 | Le Voyer et al. 2001 |
| Mmtg3 | Chr 7P | Decreased tumor burden | I/LnJ x FVB/N-TgN(MMTV-PyVT)634Mu1 | Le Voyer et al. 2001 |
| Tgfbkm2 | Chr 1D | Normal yolk sac angiogenesis | C57BL/6 Tgfb1+/− x 129S2/Sv Tgfb1+/− | Tang et al. 2003 |
| Tgfbm1 | Chr 5P | Normal yolk sac Angiogenesis | C57BL/6 Tgfb1+/− x NIH/OlaHsd Tgfb1+/− | Tang et al. 2005 |
| Tgfbm3 | Chr 12P | Normal yolk sac angiogenesis | C57BL/6 Tgfb1+/− x NIH/OlaHsd Tgfb1+/− | Tang et al. 2005 |
| AngVq1 | Chr 10M | Increased VEGF-induced angiogenesis | C57BL/6J x DBA/2J | Rogers et al. 2003, a |
| AngVq2 | Chr 2P | Decreased VEGF-induced angiogenesis | C57BL/6J x DBA/2J, C57BL/6J x A/J | Rogers et al. 2003,a |
| AngVq3 | Chr 10P | Decreased VEGF-induced angiogenesis | C57BL/6J x DBA/2J, C57BL/6J x A/J | Rogers et al. 2003,a |
| AngVq4 | Chr 7M | Decreased VEGF-induced angiogenesis | C57BL/6J x A/J | a |
| AngVq5 | Chr Y | Decreased VEGF-induced angiogenesis | C57BL/6J x A/J, C57BL/6J x SJL | a |
| AngFq1 | Chr 4P | Increased bFGF-induced angiogenesis | C57BL/6J x DBA/2J | Rogers et al. 2004 |
| AngFq2 | Chr 13P | Decreased bFGF-induced angiogenesis | C57BL/6J x DBA/2J | Rogers et al. 2004 |
| AngFq3 | Chr 15M | Increased bFGF-induced angiogenesis | C57BL/6J x DBA/2J | Rogers et al. 2004 |
| AngFq4 | Chr 18D | Increased bFGF-induced angiogenesis | C57BL/6J x DBA/2J, C57BL/6J x 129P3/J | Rogers et al. 2004 |
| AngFq5 | Chr 7P | Decreased bFGF-induced angiogenesis | C57BL/6J x SJL/J | b |
| AngFq6 | Chr 12P | Increased bFGF-induced angiogenesis | C57BL/6J x 129P3/J, C57BL/6J x 129P1/ReJ | b |
| AngFq7 | Chr 14M | Decreased bFGF-induced angiogenesis | C57BL/6J x 129P3/J | b |
| AngFq8 | Chr Y | Decreased bFGF-induced angiogenesis | C57BL/6J x A/J, C57BL/6J x SJL | b |
Quantitative trait loci (QTLs) for differences in angiogenic responsiveness along with their peak chromosomal location (P, proximal third; M, middle third; D, distal third), effect of the paternal (strain listed second) allele, and cross(es) in which the trait segregates.
aMS Rogers, AE Birsner, and RJ D'Amato, unpubl.
bMS Rogers, V Boyartchuk, AE Birsner, et al., unpubl.