Table 1.
Cell lines used for the study of the InlA- and InlB-invasion pathways
| Cell line | Species | Cell type | Receptors |
|---|---|---|---|
| Caco-2 | Human | Colorectal adenocarcinoma | E-cadherin and Met |
| CHO | Hamster | Ovary | Met |
| GPC16 | Guinea pig | Epithelial X | E-cadherin and Met |
| HeLa | Human | Cervix carcinoma | Met |
| HEp-2 | Human | Larynx carcinoma | Met |
| HepG2 | Human | Hepatocarcinoma | Met |
| JEG-3 | Human | Trophoblasts | E-cadherin and Met |
| L2071hEcad | Mouse | Fibroblasts | E-cadherin and Met |
| LoVo | Human | Colorectal carcinoma | E-cadherin and Met |
| REF-52 | Rat | Embryonic fibroblasts | Met |
| TIB73 | Mouse | Embryonic hepatocyte | Met |
| Vero | African green monkey | Kidney | Met |
Studies of the InlA and InlB pathways have been performed in different human and mammalian cell lines. Although some of them express both L. monocytogenes receptors, E-cadherin and Met, allowing the bacterium to enter by both pathways in concert or individually if either InlA or InlB is deleted, other cell lines do not express E-cadherin and can therefore only be used for studies concerning the InlB-invasion pathway.