Figure 8.
Mean residual content (±SD) of MC1220 in macaque vaginal rings after in vitro release into IPA/H2O and SVF (n = 4 in both cases), and after macaque PK and challenge studies (n = 6 in both cases). The dashed line indicates the content of MC1220 in unused rings immediately after manufacture (n = 4). One-way ANOVA indicated significant differences between the data: P < 0.0001. Post hoc statistical analysis is indicated by horizontal bars: NS, not significant; *, significant (0.01 < P < 0.05); **, very significant (0.001 < P < 0.01); ***, extremely significant (P < 0.001).