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. 2012 Oct 28;68(2):394–403. doi: 10.1093/jac/dks415

Table 1.

Inhibition of simian HIV (SHIV) and HIV-1 replication by MC1220 in vitro

Virus IC50 (ng/mL)a
MC1220 n efavirenz n
RT-SHIV162P3 0.15 ± 0.023 4 1.3 ± 0.57 2
SF162 0.41 ± 0.065 6 2.1 ± 0.44 4
SHIV162P3 >3000 5 >3000 3
DJ258 0.50 ± 0.12 4 3.5 ± 0.76 4
NL4-3 0.59 ± 0.10 4 2.7 ± 0.69 4

aThe 50% inhibitory concentration (IC50) values are means (±SEM) from n replicate TZM-bl cell assays. For MC1220 and efavirenz, 1 ng/mL corresponds to 3.4 and 3.2 nM, respectively.