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Dural afferents generate TRPV4-like currents in response to hypotonic stimuli and 4α-PDD. (A) Currents from the same representative dural afferent neuron in response to a 1 minute application of 200 mOsm or 260 mOsm solutions. Currents in response to hypotonic stimuli were observed in 56% of dural afferents. (B) Currents in response to a 1 minute application of 4α-PDD in a representative dural afferent. 4α-PDD-induced currents were observed in 49% of dural afferents.
