Table 3. Association between alopecia universalis and selected markers in the case-control analysis.

			Dominant		Recessive
Variant	Gene	Risk allele	p-value	OR	p-value	OR	1000 Genomes1	NGS Controls2
rs41559420	HLA-DRB5	A	<0.001	44.571	<0.001	-	0.014	0.005
rs28362679	BTNL2	A	<0.001	30.214	-	-	0.021	0.007
rs113337937	HLA-A	del	<0.001	18.857	-	-	-	0.088
rs116375983	HLA-DMB	T	<0.001	8.917	0.159	3.861	-	0.14
rs1805323	PMS2	T	0.001	8.125	0.332	1.683	0.348	0.31
rs117033348	TLR1	G	0.001	7.754	-	-	0.014	0.032
rs1126477	LTF	T	0.002	6.847	0.193	2.19	0.4	0.292
rs2277244	DMBT1	T	0.003	6.074	-	-	0.079	0.049
rs2297950	CHIT1	T	0.006	4.024	0.017	7.667	0.295	0.174
rs17130745	GBP4	C	0.009	6.083	0.115	-	0.033	0.026
rs78108426	CIITA	A	0.009	4.667	-	0	0.131	0.069
rs41542812	HLA-DQB1	G	0.015	5.4	0.01	-	0.058	0.037
rs75268750	C5	A	0.019	4	-	-	0.072	0.048
rs161704	IL31RA	A	0.023	3.16	0.18	2.156	0.358	0.295
rs2276872	CD96	C	0.024	3.025	0.387	2.667	0.157	0.116
rs17847215	INPPL1	C	0.036	4	-	-	0.075	0.048
rs2273346	MASP2	G	0.046	2.522	0.081	4.059	0.175	0.184
rs2738047	DEFB1	T	0.053	5.153	-	-	0.01	0.017
rs4304840	CLEC4D	G	0.06	2.413	-	0	0.154	0.14
rs116306892	MICA	C	0.084	2.227	0.069	4.553	-	0.153
rs34531670	KIR3DP1	C	0.106	2.114	0.248	2.593	-	0.14
rs4911290	C20orf185	A	0.223	3.2	0.494	1.143	0.248	0.288
rs116897146	KIR3DP1	C	0.226	1.66	0.541	1.495	-	0.139
rs1799945	HFE	G	0.289	2.254	-	-	0.024	0.023
rs1049107	HLA-DQB1	T	0.3	1.548	0.094	3.625	-	0.161
rs17611	C5	T	0.393	1.404	0.024	2.949	0.418	0.497

Abbreviations: OR, odds ratio; SNP, single nucleotide polymorphism; MAF, minor allele frequency; del, deletion; NGS, next-generation sequencing.

¹Minor allele frequency of each variant in 1000 Genomes Phase I [27].

²Minor allele frequency of each variant in 155 controls used in this study.