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. 2013 Jan 11;8(1):e53814. doi: 10.1371/journal.pone.0053814

Figure 3. AMPA-evoked adenosine release varies with diurnal cycle in the basal forebrain.

Figure 3

Animals were sacrificed at various times in the diurnal cycle and adenosine release from slices evoked by 5 µM AMPA. (a) In rat BFB, adenosine release varied with time of sacrifice, n values for each point as indicated in the figure. (b) Cumulative probability distributions of individual peak ADO’ responses at ZT 2 and 14 in rats. (c) ADO’ responses were not affected by the time slices were left to incubate following sacrifice and preparation, illustrated for slices used at ZT 6. (d) In mice, greater BFB ADO’ tone was also observed after wake periods as indicated by recordings at ZT 2 and ZT 14. Asterisks indicate significant differences, p<0.05, Mann-Whitney U test.