Figure 4. Eed^−/− and Dnmt^TKO cells have similar gene expression changes relative to wildtype cells by RNA-seq.

a, Number of genes in Dnmt^TKO and Eed^−/− cells with significant changes in expression relative to wildtype cells. b, Boxplot of mean fold change in expression level relative to wildtype. c, Venn diagram showing number of genes with significant expression level changes common to both Eed^−/− and Dnmt^TKO cells. Significance of common genes determined by chi-square test, df = 1 (p<.0001). d, Gene ontology analysis of genes commonly misregulated in both Eed^−/− and Dnmt^TKO cells. e, Classification of genes commonly misregulated in Dnmt^TKO and Eed^−/− cells based on promoter CpG content, or H3K4me3 and H3K27me3 marks. Data from [5].