Table 2.
Hematologic and biochemical studies among the four groups
| Variables | SP | CLP | CLP + H-ADMSC | CLP + A-ADMSC | p-value |
|---|---|---|---|---|---|
| At 24 hour |
|
|
|
|
|
| AST |
57 ± 7.1a |
153.7 ± 14.1b |
160.9 ± 27.5b |
126.1 ± 20.9c |
<0.001 |
| ALT |
31.9 ± 6.7 |
46.1 ± 5.1 |
46.9 ± 18.8 |
35.3 ± 11.5 |
0.06 |
| BUN |
20.3 ± 2.4 |
21.8 ± 6.9 |
22.1 ± 6.3 |
23.4 ± 9.3 |
0.849 |
| Creatinine |
0.51 ± 0.12 |
0.77 ± 0.15 |
0.74 ± 0.25 |
0.66 ± 0.14 |
0.051 |
| WBC count |
8.1 ± 2.0 |
4.9 ± 2.6 |
7.7 ± 2.5 |
6.8 ± 1.4 |
0.057 |
| At 72 hour |
|
|
|
|
|
| AST |
46.1 ± 11.1a |
106.6 ± 12.4b |
134 ± 23.4c |
81.6 ± 17.1d |
<0.001 |
| ALT |
25 ± 5.1 |
34.6 ± 10.1 |
36 ± 7.6 |
24.7 ± 14 |
0.06 |
| BUN |
16.7 ± 1.9a |
28.8 ± 6.5b |
28.3 ± 14.2b |
25 ± 5.9b |
0.018 |
| Creatinine |
0.5 ± 0.07a |
0.78 ± 0.14b |
0.83 ± 0.17b |
0.61 ± 0.11a |
<0.001 |
| WBC count | 7.7 ± 1.9a | 12.6 ± 2.8b | 9.2 ± 3.1c | 9.5 ± 2.3c | 0.016 |
Data are expressed as means ± SD.
AST = aspartate aminotransferase; ALT = alanine aminotransferase; BUN = blood urea nitrogen; WBC = white blood cell count.
SP = sham procedure; CLP = cecal ligation and puncture; H-ADMSC = healthy adipose-derived mesenchymal stem cells; A-ADMSCs = apoptotic adipose-derived mesenchymal stem cells.