Table 3.
Correlation of VLDL- and HDL-associated ApoE and ApoCIII with CAD in various lipidemic groups
| |
NL |
|
HTGa |
|
HCb |
|
HLPc |
|
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
(n=40) |
(n=15) |
|
(n=59) |
(n=11) |
|
(n=36) |
(n=29) |
|
(n=65) |
(n=35) |
|
| |
– |
+ |
|
– |
+ |
|
– |
+ |
|
– |
+ |
|
| Pvalue | Pvalue | Pvalue | Pvalue | |||||||||
|
VLDL-ApoE |
1.3±0.2 |
0.6±0.3 |
NS |
1.60±0.2 |
2.1±0.4 |
NS |
1.1±0.2 |
0.8±0.2 |
NS |
1.1±0.1 |
2.0±0.2 |
0.002 |
|
HDL-ApoE |
1.9±0.2 |
2.3±0.3 |
NS |
2.7±0.2 |
4.4±0.4 |
0.001 |
3.1±0.2 |
2.8±0.2 |
NS |
3.8±0.1 |
4.1±0.2 |
NS |
|
VLDL-ApoCIII |
6.4±0.7 |
4.7±1.0 |
NS |
9.3±0.6 |
3.8±1.3 |
0.0004 |
14.0±0.7 |
5.9±0.8 |
0.0001 |
9.6±0.5 |
5.1±0.7 |
0.0001 |
|
HDL-ApoCIII |
8.3±0.5 |
13.7±0.8 |
0.0001 |
7.5±0.4 |
12.1±1.0 |
0.0001 |
7.2±0.5 |
12.0±0.6 |
0.0001 |
12.7±0.4 |
11.4±0.5 |
NS |
| HDL-ApoCIII to VLDL-ApoCIII ratio | 1.8±0.5 | 4.6±0.7 | 0.002 | 1.1±0.4 | 8.4±1.0 | 0.0001 | 0.6±0.5 | 3.6±0.6 | 0.0001 | 1.6±0.4 | 4.2±0.5 | 0.0001 |
Data are presented as mean ± standard error of the mean, and all units are mg/dL, except for the HDL-ApoCIII to VLDL-ApoCIII ratio.
VLDL = very low-density lipoprotein; HDL = high-density lipoprotein; Apo = apolipoprotein; CAD = coronary artery disease; NL = normolipidemic; HTG = hypertriglyceridemic; HC = hypercholesterolemic; HLP = hyperlipidemic; NS = nonsignificant.
aTG > 150 mg/dL.
bTC > 200 mg/dL.
cHC + HTG.