Figure 1. Overview of the computational model for steroidogenesis last metabolic steps in a rat granulosa cell.

The transcription and translation events for the three last major enzymes involved in estradiol synthesis, and sex steroid synthesis itself, are modeled, with relevant FSH control, endocrine disrupting chemical (EDC) modulation, or methoxychlor (MXC) aromatase competitive inhibition. Steroids can be transported in and out of cell. In vitro, the exterior compartment corresponds to the culture medium; in vivo it corresponds to the ovary tissue (see Figure 2). Aliases (repeated species labels) are used for clarity but correspond in fact to a unique species.