Table 3. Prior distributions of the model parameters (for one granulosa cell) to be calibrated by MCMC sampling.

Parameter (units)	Symbol	Prior distribution
FSH effect on aromatase mRNA transcription (/pg FSH)	κCyp 19	U (0, 1×107)a
FSH effect on Hsd17b1 mRNA transcription (/pg FSH)	κHsd 17b1	U (0, 1×106)a
Maximal reaction rates Vmax (pmoles/min/pg enzyme)
Aromatase
A → E1 reaction	λCyp 19,A	LN (1.33×10−7, 1.2)a,b,c,d
T → E2 reaction	λCyp 19,T	LN (1.33×10−7, 2.0)d
Hsd17b1
A → T reaction	λHsd 17b1,A	LN (7.59×10−8, 2.0)e,f,g
E1 → E2 reaction	λHsd 17b1,E1	LN (1.03×10−5, 2.0)e,f,g
Michaelis-Menten constants (pmoles)
Aromatase
For A	ξCyp 19,A	LN (8.10×10−9, 1.2) a,b,c,d
For T	ξCyp 19,T	LN (3.24×10−8, 2.0)d
Hsd17b1
For A	ξHsd 17b1,A	LN (4.32×10−5, 2.0) e,f,g
For E1	ξHsd 17b1,E1	LN (5.29×10−6, 2.0) e,f,g
Mean inter-study random effect (arbitrary unit)	µ 0	LN (1, 2.0)
Measurement variance for inter-study random effects	Σ 1	HN (0.5)
Measurement variance for data likelihood of mRNA and proteins	Σ 2	HN (0.2)
Measurement variance for data likelihood of hormone measurements	Σ 3	HN (0.2)

LN (geometric mean, geometric SD): lognormal distribution; U (min, max): uniform distribution; HN (SD): halfnormal distribution with mean at zero.

Prior distribution for V_max and K_m parameters and for FSH effects are obtained and estimated from direct measurements on granulosa cells in vitro.

^aQuignot et al., 2012a [20].

^bOdum et al., 2001 [51].

^cAuvray et al., 2002 [46].

^dKrekels et al., 1990 [52].

^eIshikura et al., 2006 [53].

^fRenwick et al., 1981 [49].

^gSteckelbroeck et al., 2003 [54].