Table 4. Summary statistics of the parameter posterior distributions after Bayesian calibration of the in vitro model.

Parameter	Average	SD	Maximum a posteriori probability estimates	0.5 percentile	2.5 percentile	97.5 percentile	99.5 percentile
κCyp 19	2.08×106	4.04×105	2.08×106	1.20×106	1.36×106	2.97×106	3.27×106
κHsd 17b1	4.55×105	1.76×105	6.04×105	1.08×105	1.59×105	8.51×105	9.38×105
λCyp 19,A	1.04×10−7	1.78×10−8	1.07×10−7	6.54×10−8	7.36×10−8	1.44×10−7	1.59×10−7
λCyp 19,T	3.72×10−7	2.16×10−7	2.67×10−7	8.39×10−8	1.15×10−7	9.61×10−7	1.33×10−6
λHsd 17b1,A	1.03×10−7	7.86×10−8	5.65×10−8	1.30×10−8	2.12×10−8	3.14×10−7	4.76×10−7
λHsd 17b1,E1	3.22×10−5	1.98×10−5	1.78×10−5	6.59×10−6	9.42×10−6	8.57×10−5	1.06×10−4
ξCyp 19,A	8.32×10−9	1.53×10−9	8.25×10−9	5.16×10−9	5.7×10−9	1.17×10−8	1.32×10−8
ξCyp 19,T	4.12×10−8	3.18×10−8	1.24×10−8	5.55×10−9	8.29×10−9	1.24×10−7	1.7×10−7
ξHsd 17b1,A	6.49×10−5	4.93×10−5	4.84×10−5	9.58×10−6	1.38×10−5	1.98×10−4	2.74×10−4
ξHsd 17b1,E1	2.91×10−6	1.96×10−6	1.30×10−6	4.74×10−7	6.61×10−7	8.00×10−6	1.12×10−5
µ 0	0.407	0.163	1.46	0.131	0.177	0.81	1.08
Σ 1	1.43	0.295	0.265	0.803	0.911	2.07	2.24
σL 1	1.07	2.1	0.117	0.0144	0.0367	5.42	19
σL 2	1.86	0.817	1.99	0.552	0.728	3.85	5.1
σL 3	0.0376	0.0181	0.0293	0.0109	0.0143	0.0839	0.116
σL 4	0.0314	0.0148	0.0193	0.00923	0.0122	0.0667	0.0938
σL 5	4.78	2.94	2.86	1.12	1.47	12.3	18.6
σL 6	0.028	0.0127	0.0213	0.00912	0.0111	0.0612	0.0808
σL 7	0.158	0.0306	0.153	0.0938	0.107	0.226	0.259
σL 8	0.696	0.422	0.612	0.129	0.188	1.75	2.48
σL 9	0.971	1.63	0.114	0.0182	0.0329	4.88	11.7
σL 10	0.685	0.101	0.685	0.46	0.506	0.916	1.03
Σ 2	0.648	0.0842	0.626	0.47	0.503	0.832	0.901
Σ 3	0.48	0.111	0.501	0.251	0.29	0.752	0.802

Each σ_Li corresponds to the specific inter-study random effect σ_L for each simulation set described in Information S1.