Table 2. Gene expression measured by genome-wide microarray profiling after 4 h of endotoxin stimulation in polymorphonuclear cells (PMNs) and monocytes (MONOs) from the newly born (N = 5).

Gene Name*	Gene ID	Gene Identifier	PMNs			MONOs
			Fold Change		p value	Fold Change		p value
Chemokine (C-C motif) ligand 2	CCL2	S69738 g	Up	6.2	0.0154	Up	22.4	0.0010
Chemokine (C-C motif) ligand 3	CCL3	NM_002983 g	Up	3.6	0.0071	Up	3.5	0.0017
Chemokine (C-C motif) ligand 4	CCL4	NM_002984 g	Up	4.1	0.0041	Up	3.7	0.0092
Chemokine (C-C motif) ligand 5	CCL5	NM_002985 g	Up	1.7	0.0072	Up	7.2	0.0011
Chemokine (C-C motif) ligand 7	CCL7	NM_006273 g	–	2.0	NS	Up	63.5	0.0009
chemokine (C-C motif) ligand 8	CCL8	AI984980 g	–	1.2	NS	Up	63.9	<0.0001
Chemokine (C-X-C motif) ligand 10	CXCL10	NM_001565 g	–	1.1	NS	Up	26.0	0.0002
Colony stimulating factor 2 (granulocyte-macrophage)	CSF2	M11734 g	–	2.3	NS	Up	2.2	0.0092
Colony stimulating factor 3 (granulocyte)	CSF3	NM_000759 g	Up	5.6	0.0028	Up	26.9	0.0001
Integrin, beta 8	ITGB8	NM_002214 g	Up	18.13	0.0004	Up	55.3	<0.0001
Intercellular adhesion molecule 1	ICAM1	NM_000201 g	Up	3.3	0.0008	Up	3.2	0.0048
Interleukin 1 receptor antagonist	IL1RN	AW083357 g	Up	9.9	0.0122	Up	24.1	0.0013
Interleukin 1, alpha	IL1A	M15329 g	Up	29.3	0.0113	Up	10.0	0.0044
Interleukin 1, beta	IL1B	NM_000576 g	Up	6.2	0.0129	Up	2.6	0.0071
Interleukin 10	IL10	NM_000572 g	–	2.5	NS	Up	55.4	<0.0001
Interleukin 12B	IL12B	NM_002187 g	Up	3.5	0.0378	Up	16.6	0.0095
Interleukin 16 (lymphocyte chemoattractant factor)	IL16	NM_004513 g	Down	2.1	0.0363	–	1.5	NS
Interleukin 18 (interferon-gamma-inducing factor)	IL18	NM_001562 g	Down	2.3	0.0001	–	1.6	0.045
Interleukin 2 receptor, alpha	IL2RA	NM_000417 g	–	1.7	NS	Up	37.0	0.0002
Interleukin 6 (interferon, beta 2)	IL6	NM_000600 g	Up	181.8	0.0007	Up	95.7	0.0014
Interleukin 7	IL7	NM_000880 g	–	1.1	NS	Up	6.1	0.0002
Interleukin 8	IL8	NM_000584 g	–	1.2	NS	–	1.6	NS
Transforming growth factor, beta 1	TGFB1	BC000125 g	Down	1.7	0.041	Down	1.6	0.0032
Tumor necrosis factor (TNF superfamily, member 2)	TNF	NM_000594 g	Up	7.1	0.0122	Up	4.0	0.02343

^*Genes were selected based on previous clinical studies of the fetal inflammatory response syndrome and bronchopulmonary dysplasia [10], [20], [23].