Table 3. Pathways for genes changing expression (fold changes) measured by genome-wide microarray after 4 h of endotoxin stimulation in polymorphonuclear leukocytes (PMNs) and monocytes (MONOs) of the newly born (N = 5).
| Unique to PMNs | Common | Unique to MONOs | ||||
| KEGG Pathway* | Up | Down | Up | Down | Up | Down |
| JAK/STAT signaling pathway | – | – | – | – | 24 (3.7) | – |
| Cytokine-cytokine receptor interaction | – | 13 (−2.0) | 22 (5.3) | 6 (−2.6) | 42 (5.0) | 16 (−2.4) |
| NOD-like receptor signaling pathway | 8 (4.6) | – | 11 (7.1) | – | 9 (2.0) | – |
| Osteoclast differentiation | 11 (3.7) | – | 11 (4.0) | – | 18 (2.8) | 25 (3.6) |
| Apoptosis | – | – | 10 (4.7) | – | – | – |
| RIG-I-like receptor signaling pathway | 6 (2.6) | – | 8 (4.2) | – | – | – |
| Toll-like receptor signaling pathway | – | – | 13 (6.0) | – | – | – |
| MAPK signaling pathway | – | – | 18 (3.8) | – | – | – |
| Chemokine signaling pathway | – | – | 14 (3.9) | – | 26 (3.3) | – |
| Fc gamma R-mediated phagocytosis | – | – | – | – | 18 (4.4) | 15 (2.1) |
| Metabolic pathways | – | – | – | 88 (3.6) | 64 (−2.5) | 153 (4.7) |
| Pentose phosphate pathway | – | – | – | 6 (3.8) | – | 6 (2.2) |
| Phosphatidylinositol signaling system | – | – | – | 12 (3.6) | – | 14 (2.2) |
| Phagosome | 12 (3.6) | – | – | – | – | 23 (2.17) |
| Protein processing in endoplasmic reticulum | – | – | – | – | 25 (3.7) | – |
| Ubiquitin-mediated proteolysis | – | 25 (4.6) | – | – | – | – |
*
KEGG = Kyoto Encyclopedia of Genes and Genomes. (values) are z scores with significance 2<Z<−2.