Table 1. Clinical, virological and histological features of pediatric CHC patients.
| Clinical and serological characteristics | Histological characteristics | |||||||||||
| Pediatric Patients | Sex | Ages (ys) | Risk factor for HCV infection | Genotype | Transaminases | Knodell | Fibrosis stages # | Lymphoid Follicle | Bile duct damage | Steatosis | ||
| AST (U/L) | ALT (U/L) | |||||||||||
| 1 | M | 13 | T | 1a | 47 | 43 | 8(5+3) | F2 | no | no | absent | |
| 2 | F | 14 | T | 1b | 55 | 86 | 11(9+2) | F1 | no | no | minimal | |
| 3 | F | 4 | V | 1a/c | 46 | 34 | 10(7+3) | F2 | yes | yes | absent | |
| 4 | F | 17 | T | 1a/c | 39 | 43 | 8(4+4) | F3 | no | yes | moderate | |
| 5 | M | 4 | V | 1a/c | 84 | 97 | 10(9+1) | F1 | yes | yes | severe | |
| 6 | BxI | F | 6 | V | 1a/c | 13 | 11 | 7(3+4) | F3 | no | no | absent |
| BxII | 13 | 23 | 21 | 8(5+3) | F2 | no | yes | minimal | ||||
| 7 | F | 16 | Unknown | 1a/c | 30 | 41 | 12(10+2) | F1 | yes | yes | minimal | |
| 8 | BxI | M | 3 | V | 1a/c | 71 | 91 | 6(5+1) | F1 | yes | yes | minimal |
| BxII | 6 | 314 | 364 | 11(8+3) | F2 | no | yes | severe | ||||
| BxIII | 13 | 225 | 260 | 21(16+5) | F3 | no | yes | moderate | ||||
| 9 | F | 6 | V | 1a/c | 35 | 50 | 8(7+1) | F1 | yes | yes | minimal | |
| 10 | F | 8 | Unknown | 1a | 41 | 38 | 9(7+2) | F1 | yes | yes | absent | |
| 11 | M | 13 | Unknown | ND | 56 | 71 | 10(7+3) | F2 | no | yes | absent | |
| 12 | F | 17 | V | 1a/c | 21 | 11 | 6(3+3) | F2 | no | yes | minimal | |
| 13 | F | 3 | V | 1a/c | 84 | 137 | 6(5+1) | F1 | no | yes | moderate | |
| 14 | F | 3 | V | 1b | 65 | 75 | 9(6+3) | F2 | yes | yes | moderate | |
| 15 | F | 1 | V | 4 | 57 | 33 | 11(7+4) | F3 | yes | yes | absent | |
| 16 | F | 17 | T | 1a/c | 22 | 16 | 10(7+3) | F2 | no | yes | minimal | |
| 17 | M | 1 | T | 1b | 159 | 213 | 14(11+3) | F2 | yes | yes | minimal | |
| 18 | F | 8 | T | 1b | 10 | 12 | 6(5+1) | F1 | no | no | absent | |
| 19 | M | 15 | T | ND | 58 | 76 | 15(10+5) | F3 | no | yes | absent | |
| 20 | F | 6 | V | 1a/c | 56 | 55 | 6(5+1) | F1 | no | yes | severe | |
| 21 | M | 15 | T | 1b | 20 | 24 | 13(10+3) | F2 | yes | yes | absent | |
| 22 | M | 12 | Unknown | 1a/c | 83 | 113 | 11 (8+3) | F2 | no | yes | minimal | |
F: female, M: male. ND: not determined Bx I, Bx II, Bx III denote: multiple liver biopsies. Risk factor for HCV infection: T: transfusion, V: vertical transmission.
ALT: alanine aminotransferase; AST: aspartate aminotransferase. Normal ALT and AST levels were ≤32 and ≤48 IU/L, respectively when test was done at 37°C.
#
Fibrosis stages according METAVIR.