Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Psychiatry. 2012 Oct 9;18(12):1273–1280. doi: 10.1038/mp.2012.136

Figure 1.

Figure 1

Effects of maternal strain and chronic fluoxetine treatment on depression- and anxiety-like behavior of F1 mice. F1 mice were generated from reciprocal cJ × B6 outcrosses. F1 mice with cJ dams showed significantly less immobility in the FST than F1 mice with B6 dams, and chronic fluoxetine (18mg/kg/day) treatment reduced immobility across F1 strains (a). Neither dam strain nor fluoxetine treatment altered swimming behavior in the FST (b). Fluoxetine treatment increased climbing behavior across F1 strains in the FST (c). Neither dam strain nor fluoxetine treatment altered time in the dark side (d), or transitions (e) in the light/dark test, or center time (f) or distance traveled (g) in the open field test. Bars represent mean ± SEM (n=15 mice per group).