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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Psychiatry. 2012 Oct 9;18(12):1273–1280. doi: 10.1038/mp.2012.136

Figure 4.

Figure 4

Differential methylation of the αCGRP gene in F1 hybrid strains. Analysis of DNA methylation at the mouse αCGRP locus by sequencing of clones obtained from sodium bisulfate-treated genomic DNA extracted from the hippocampus (a). The percent methylation of the promoter region spanning 0 – 800 bp upstream of the transcription initiation site was higher than in exon 1 and intron 1 (b). The percent methylation of the αCGRP promoter region was higher in F1 mice gestated by cJ dams (c). Post hoc tests indicated that percent methylation of four specific CpG sites in the promoter region were higher in F1 mice gestated by cJ dams (a). Rearing condition had no effect on methylation of the αCGRP promoter region (d). Bars represent mean ± SEM (n=15 mice per group).