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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Autoimmunity. 2012 Nov 1;46(1):21–31. doi: 10.3109/08916934.2012.732133

Figure 2.

Figure 2

MTA and SAM inhibit T cell and/or B cell proliferation. (A) Purified T and B cells from B10.BR mice were stimulated in the presence of various concentrations of MTA or SAM (see Materials and Methods). Six independent results are represented as the percentage of the stimulation control response (% ± S.D. of the mean). (B) CD4+ T cells were purified from placebo-, MTA-treated and SAM-treated OVA immunized B10.BR mice (n = 6 for each group). The proliferative response against immunizing antigen (OVA) or general TCR engagement (anti-CD3 plus anti-CD28 mAb) was evaluated by [3H] thymidine incorporation as described in Materials and Methods. Positive control PPD responses were >68,000 cpm. ★, p < 0.05 for comparison to placebo group.