Table 1.
Hazard Ratios for associations between Troponin T and mortality, ARIC, 1996-2008
| Hazard ratio (95% Confidence Interval) |
||||||
|---|---|---|---|---|---|---|
| <3ng/L | 3- ≤5ng/L | 6-≤ 8ng/L | 9- ≤13ng/L | ≥14ng/L | P for trend | |
| N | 3544 | 2779 | 2269 | 1535 | 1066 | |
| Total mortality (n=1909) Events | 306 | 349 | 359 | 394 | 501 | |
| Model 1 | 1 | 1.26 (1.07- 1.47) | 1.37 (1.16- 1.61) | 2.02 (1.71- 2.38) | 4.34 (3.68- 5.12) | <0.0001 |
| Model 2 | 1 | 1.38 (1.13- 1.67) | 1.53 (1.25- 1.86) | 1.91 (1.55- 2.35) | 3.42 (2.75- 4.26) | <0.0001 |
| Model 3 | 1 | 1.32 (1.09- 1.61) | 1.42 (1.16- 1.74) | 1.73 (1.40- 2.13) | 2.82 (2.26- 3.53) | <0.0001 |
| All CVD mortality (n=358 ) Events | 51 | 63 | 64 | 77 | 103 | |
| Model 1 | 1 | 1.42 (0.98- 2.07) | 1.67 (1.14- 2.44) | 2.88 (1.97- 4.20) | 7.71 (5.31- 11.2) | <0.0001 |
| Model 2 | 1 | 1.50 (0.96- 2.36) | 1.89 (1.20- 2.97) | 3.01 (1.91- 4.75) | 7.34 (4.64- 11.6) | <0.0001 |
| Model 3 | 1 | 1.41 (0.90- 2.22) | 1.70 (1.08- 2.66) | 2.54 (1.60- 4.01) | 5.09 (3.18- 8.15) | <0.0001 |
| CHD mortality (n= 138) Events | 19 | 24 | 30 | 28 | 37 | |
| Model 1 | 1 | 1.37 (0.74- 2.51) | 1.89 (1.04- 3.43) | 2.42 (1.29- 4.51) | 6.22 (3.37- 11.5) | <0.0001 |
| Model 2 | 1 | 1.28 (0.61- 2.68) | 2.17 (1.09- 4.35) | 2.42 (1.16- 5.06) | 6.06 (2.91- 12.6) | <0.0001 |
| Model 3 | 1 | 1.25 (0.60- 2.63) | 2.03 (1.01- 4.07) | 2.22 (1.06- 4.64) | 4.65 (2.19- 9.89) | <0.0001 |
| Stroke mortality (n= 67) Events | 17 | 15 | 5 | 14 | 16 | |
| Model 1 | 1 | 0.98 (0.48- 1.97) | 0.38 (0.14- 1.06) | 1.53 (0.71- 3.32) | 3.87 (1.78- 8.41) | 0.003 |
| Model 2 | 1 | 1.00 (0.43- 2.29) | 0.31 (0.09- 1.14) | 1.89 (0.78- 4.58) | 3.31 (1.26- 8.66) | 0.02 |
| Model 3 | 1 | 0.91 (0.39- 2.09) | 0.28 (0.08- 1.02) | 1.57 (0.64- 3.85) | 2.34 (0.86- 6.33) | 0.09 |
| Cancer Mortality (n= 502) Events | 127 | 119 | 105 | 81 | 70 | |
| Model 1 | 1 | 0.99 (0.76- 1.28) | 0.87 (0.66- 1.14) | 0.90 (0.66-1.23) | 1.28 (0.91- 1.80) | 0.60 |
| Model 2 | 1 | 1.15 (0.85- 1.54) | 1.04 (0.75- 1.43) | 1.02 (0.71- 1.46) | 1.60 (1.08- 2.38) | 0.17 |
| Model 3 | 1 | 1.14 (0.84- 1.53) | 1.02 (0.74- 1.41) | 0.99 (0.69- 1.43) | 1.52 (1.01- 2.28) | 0.27 |
| Respiratory disease mortality (n= 99) Events | 15 | 14 | 24 | 23 | 23 | |
| Model 1 | 1 | 0.91 (0.43- 1.95) | 1.69 (0.85- 3.38) | 2.11 (1.02- 4.35) | 3.84 (1.82- 8.10) | <0.0001 |
| Model 2 | 1 | 1.15 (0.42- 3.12) | 2.34 (0.94- 5.78) | 2.48 (0.96- 6.45) | 3.85 (1.39- 10.7) | 0.004 |
| Model 3 | 1 | 1.12 (0.41- 3.03) | 2.26 (0.91- 5.62) | 2.48 (0.95- 6.51) | 3.80 (1.35- 10.7) | 0.004 |
CHD- indicates coronary heart disease, CVD- indicates cardiovascular disease, P for linear trend across categories
Model 1- adjusted for age, sex and race
Model 2- adjusted for model 1 + body mass index, total cholesterol, high density lipoprotein cholesterol, diet, sport index, smoking status, drinking status, hormone use, systolic blood pressure, antihypertensive medication, diabetes, forced expiratory volume in 1 second/forced vital capacity predicted %, estimated glomerular filtration rate. In addition, total mortality was adjusted for history of cancer, CVD, stroke, heart failure and respiratory disease
Model 3- adjusted for model 2 + high sensitivity C- reactive protein (Hs-CRP) and N terminal pro B natriuretic peptide (NT-proBNP)