Table 3.
Hazard Ratios for associations between C reactive protein and mortality, ARIC, 1996-2008
| Hazard ratio (95% Confidence Interval) |
||||||
|---|---|---|---|---|---|---|
| ≤0.9mg/L | 0.917-1.761 mg/L | 1.762-3.389mg/L | 3.390-6.578mg/L | ≥6.579mg/L | P for trend | |
| N | 2238 | 2239 | 2239 | 2239 | 2238 | |
| Total mortality (n=1909) Events | 302 | 328 | 331 | 430 | 518 | |
| Model 1 | 1 | 1.07 (0.91- 1.26) | 1.13 (0.96- 1.32) | 1.63 (1.40- 1.90) | 2.14 (1.84- 2.49) | <0.0001 |
| Model 2 | 1 | 1.05 (0.87- 1.27) | 1.14 (0.94- 1.38) | 1.48 (1.22- 1.79) | 1.61 (1.32- 1.97) | <0.0001 |
| Model 3 | 1 | 1.07 (0.88- 1.29) | 1.12 (0.93- 1.36) | 1.40 (1.16- 1.70) | 1.46 (1.20- 1.78) | <0.0001 |
| All CVD mortality (n= 358) Events | 62 | 68 | 50 | 77 | 101 | |
| Model 1 | 1 | 1.12 (0.79- 1.58) | 0.85 (0.59- 1.24) | 1.44 (1.03- 2.02) | 2.09 (1.51- 2.90) | <0.0001 |
| Model 2 | 1 | 1.07 (0.73- 1.59) | 0.85 (0.56- 1.30) | 1.26 (0.85- 1.88) | 1.76 (1.19- 2.62) | 0.004 |
| Model 3 | 1 | 1.11 (0.75- 1.65) | 0.85 (0.56- 1.31) | 1.15 (0.77- 1.72) | 1.49 (1.00- 2.21) | 0.06 |
| CHD mortality (n= 138) Events | 21 | 25 | 20 | 36 | 36 | |
| Model 1 | 1 | 1.22 (0.68- 2.18) | 1.03 (0.56- 1.90) | 2.10 (1.22- 3.62) | 2.43 (1.40- 4.22) | 0.0002 |
| Model 2 | 1 | 1.08 (0.57- 2.03) | 0.98 (0.50- 1.91) | 1.66 (0.89- 3.09) | 1.88 (0.98- 3.59) | 0.02 |
| Model 3 | 1 | 1.12 (0.59- 2.12) | 0.98 (0.50- 1.91) | 1.52 (0.81- 2.84) | 1.66 (0.87- 3.18) | 0.08 |
| Stroke mortality (n= 67) Events | 16 | 14 | 9 | 8 | 20 | |
| Model 1 | 1 | 0.88 (0.43- 1.80) | 0.58 (0.26- 1.32) | 0.56 (0.24- 1.31) | 1.58 (0.80- 3.12) | 0.45 |
| Model 2 | 1 | 1.17 (0.50- 2.74) | 0.90 (0.35- 2.31) | 0.90 (0.33- 2.44) | 2.24 (0.90- 5.53) | 0.21 |
| Model 3 | 1 | 1.15 (0.49- 2.73) | 0.93 (0.36- 2.38) | 0.85 (0.31- 2.34) | 1.91 (0.77- 4.71) | 0.33 |
| Cancer Mortality (n= 502) Events | 82 | 99 | 103 | 110 | 108 | |
| Model 1 | 1 | 1.23 (0.92- 1.66) | 1.35 (1.01- 1.82) | 1.61 (1.20- 2.16) | 1.72 (1.27- 2.33) | <0.0001 |
| Model 2 | 1 | 1.12 (0.81- 1.56) | 1.31 (0.94- 1.81) | 1.35 (0.96- 1.91) | 1.38 (0.95- 2.00) | 0.05 |
| Model 3 | 1 | 1.14 (0.82- 1.59) | 1.31 (0.94- 1.82) | 1.34 (0.95- 1.89) | 1.35 (0.93- 1.96) | 0.07 |
| Respiratory disease mortality (n= 99) Events | 14 | 15 | 15 | 20 | 35 | |
| Model 1 | 1 | 1.01 (0.47- 2.19) | 1.20 (0.56- 2.56) | 2.02 (1.00- 4.07) | 4.01 (2.08- 7.73) | <0.0001 |
| Model 2 | 1 | 1.57 (0.63- 3.87) | 1.34 (0.52- 3.45) | 2.08 (0.83- 5.22) | 3.36 (1.34- 8.45) | 0.01 |
| Model 3 | 1 | 1.65 (0.66- 4.11) | 1.41 (0.54- 3.66) | 2.09 (0.83- 5.26) | 3.38 (1.34- 8.50) | 0.01 |
CHD- indicates coronary heart disease, CVD- indicates cardiovascular disease, P for linear trend across quintiles
Model 1- adjusted for age, sex and race
Model 2- adjusted for model 1 + body mass index, total cholesterol, high density lipoprotein cholesterol, diet, sport index, smoking status, drinking status, hormone use, systolic blood pressure, antihypertensive medication, diabetes, forced expiratory volume in 1 second/forced vital capacity predicted %, estimated glomerular filtration rate. In addition, total mortality was adjusted for history of cancer, CVD, stroke, heart failure and respiratory disease
Model 3- adjusted for model 2 + troponin T and N terminal pro B natriuretic peptide (NT-proBNP)