Table 4.
Hazard Ratios for Joint associations of elevated Troponin T, NT-proB natriuretic peptide, or C reactive protein with mortality, ARIC 1996-2008
| Hazard ratio (95% Confidence Interval) according to number elevated a |
||||
|---|---|---|---|---|
| 0 | 1 | 2 | 3 | |
| N | 5899 | 3789 | 1227 | 278 |
| Total mortality (n=1909) | 569 | 692 | 470 | 178 |
| Model 2 | 1 | 1.50 (1.31- 1.72) | 2.31 (1.94- 2.74) | 4.31 (3.31- 5.63) |
| All CVD mortality (n=358) | 93 | 135 | 99 | 31 |
| Model 2 | 1 | 2.06 (1.51- 2.81) | 5.12 (3.61- 7.25) | 10.5 (6.38- 17.3) |
| CHD mortality (n= 138) | 44 | 44 | 41 | 9 |
| Model 2 | 1 | 1.22 (0.75- 1.99) | 4.11 (2.45- 6.90) | 6.18 (2.68- 14.3) |
| Stroke mortality (n=67) | 19 | 25 | 15 | 8 |
| Model 2 | 1 | 2.09 (1.04- 4.22) | 4.87 (2.18- 10.9) | 12.0 (3.61- 40.2) |
| Cancer Mortality (n= 502) | 227 | 194 | 62 | 19 |
| Model 2 | 1 | 1.13 (0.90- 1.42) | 1.14 (0.80- 1.63) | 1.99 (1.00- 3.98) |
| Respiratory disease mortality (n= 99) | 28 | 41 | 19 | 11 |
| Model 2 | 1 | 1.27 (0.69- 2.34) | 1.70 (0.78- 3.74) | 5.14 (1.61- 16.4) |
CHD- indicates coronary heart disease, CVD- indicates cardiovascular disease, model 1- adjusted for age, sex and race
elevated was defined by being above versus below the 80th percentile for each biomarker
Adjusted for model 1+ body mass index, total cholesterol, high density lipoprotein cholesterol, diet, sport index, smoking status, drinking status, hormone use, systolic blood pressure, antihypertensive medication, diabetes, forced expiratory volume in 1 second/forced vital capacity predicted %, estimated glomerular filtration rate. In addition, total mortality was adjusted for history of cancer, CVD, stroke, heart failure and respiratory disease