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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Addict Biol. 2012 Oct 8;18(3):405–416. doi: 10.1111/j.1369-1600.2012.00499.x

Figure 1.

Figure 1

Study Design Illustration of Within-Subject Crossover Pretreatments with Digram-Balanced Latin-Square (LS) Counterbalanced Sequences of Cocaine Dosing After 5 Days of Pretreatment Stabilization.

Topiramate (100 mg twice daily) and placebo were given as crossover pretreatments for 1 week each. After 5 days of stabilization, three intravenous (i.v.) doses of saline or cocaine (0.325 or 0.65 mg/kg) were administered over 3 days (Days 6–8) in an order completely counterbalanced across a group of 6 subjects. Day 9 was the day of delivery of a money-versus-cocaine choice from the Multiple Choice Questionnaire.