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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Addict Biol. 2012 Oct 8;18(3):405–416. doi: 10.1111/j.1369-1600.2012.00499.x

Figure 2.

Figure 2

Effects of Topiramate on Cocaine Dose-Related Activation of Euphoria, Stimulation, Craving, and Behavioral Preference for Additional Cocaine.

Shown are the mean ± SEM Euphoria, Stimulated, and Craving factor score ratings from the Visual Analog Scale (VAS) and the Crossover Price from the Multiple Choice Questionnaire (MCQ). Data are means ± SEM from the N=24 subjects given cocaine doses (mg/kg) intravenously (i.v.) after oral pretreatment with placebo or topiramate (100 mg twice daily). *Topiramate was significantly different from placebo at the same cocaine dose.