Table 2.
Cocaine and Topiramate Effects on Subjective Mood
| Least Squares Means (95% Confidence Intervals) | ANOVA Table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo Topiramate | 100 mg Topiramate | Main Effect of Cocaine | Main Effect of Topiramate | Interaction of Cocaine and Topiramate | ||||||||
| Subjective Mood Subscale | 0 mg/kg Cocaine | 0.325 mg/kg Cocaine | 0.65 mg/kg Cocaine | 0 mg/kg Cocaine | 0.325 mg/kg Cocaine | 0.65 mg/kg Cocaine | F | P | F | P | F | P |
| ARCI | ||||||||||||
| MBG (euphoria) | 6.1 (5.3, 7.0) | 5.6 (4.8, 6.5) | 7.1 (6.3, 8.0) | 7.1 (6.2, 7.9) | 7.7* (6.8, 8.5) | 6.6 (5.7, 7.4) | 0.23 | 0.80 | 7.27 | 0.014 | 4.21 | 0.023 |
| BG (benzedrine) | 4.5 (3.9, 5.1) | 4.9 (4.3, 5.5) | 5.0 (4.4, 5.6) | 4.4 (3.8, 5.0) | 5.3 (4.7, 5.9) | 5.2 (4.6, 5.8) | 4.10 | 0.025 | 0.34 | 0.57 | 0.49 | 0.62 |
| A (amphetamine) | 4.2 (3.5, 4.8) | 4.3 (3.7, 5.0) | 4.5 (3.9, 5.2) | 4.1 (3.5, 4.7) | 5.0 (4.3, 5.7) | 4.2 (3.5, 4.8) | 1.36 | 0.27 | 0.13 | 0.73 | 1.40 | 0.26 |
| LSD (dysphoria) | 2.8 (2.1, 3.6) | 3.6 (2.8, 4.3) | 4.3 (3.6, 5.0) | 2.9 (2.1, 3.6) | 3.7 (3.0, 4.4) | 3.4* (2.7, 4.1) | 12.77 | 0.0001 | 1.21 | 0.29 | 5.47 | 0.011 |
| PCAG (sedation) | 2.4 (2.0, 2.8) | 3.5 (3.2, 3.9) | 3.9 (3.5, 4.2) | 2.4 (2.0, 2.7) | 3.3 (2.9, 3.6) | 3.2* (2.8, 3.5) | 18.57 | 0.0001 | 9.05 | 0.008 | 4.97 | 0.018 |
| POMS | ||||||||||||
| FRD (friendliness) | 16.5 (15.2, 17.8) | 15.38 (14.0, 16.7) | 15.1 (13.9, 16.4) | 15.7 (14.4, 16.9) | 15.4 (14.1, 16.6) | 14.8 (13.6, 16.1) | 1.66 | 0.20 | 0.48 | 0.49 | 0.26 | 0.77 |
| TA (tension-anxiety) | 3.0 (2.0, 4.0) | 4.3 (3.3, 5.3) | 5.7 (4.7, 6.7) | 3.1 (2.2, 4.1) | 4.4 (3.4, 5.4) | 4.6 (3.6, 5.6) | 11.36 | 0.0001 | 0.61 | 0.45 | 1.52 | 0.23 |
| AH (anger-hostility) | 3.2 (2.6, 3.9) | 3.0 (2.3, 3.7) | 2.4 (1.7, 3.1) | 2.8 (2.2, 3.5) | 2.8 (2.1, 3.4) | 2.7 (2.1, 3.4) | 4.78 | 0.01 | 0.15 | 0.70 | 2.73 | 0.08 |
| FAT (fatigue) | 0.7 (0.2, 1.2) | 0.8 (0.3, 1.3) | 0.6 (0.1, 1.1) | 1.0 (0.5, 1.5) | 0.4 (0, 0.9) | 1.4* (0.9, 1.9) | 1.95 | 0.15 | 2.06 | 0.15 | 4.82 | 0.01 |
| VIG (vigor) | 14.9 (13.5, 16.3) | 14.1 (12.7, 15.5) | 15.7 (14.3, 17.1) | 14.7 (13.3, 16.1) | 14.8 (13.4, 16.1) | 13.2 (11.9, 14.6) | 0.19 | 0.82 | 1.43 | 0.24 | 2.86 | 0.06 |
| CB (confusion-bewilderment) | 2.6 (2.0, 3.3) | 3.0 (2.4, 3.7) | 3.6 (3.0, 4.3) | 3.7* (3.1, 4.3) | 3.2 (2.6, 3.8) | 3.7 (3.1, 4.3) | 5.89 | 0.006 | 2.65 | 0.13 | 4.47 | 0.020 |
| DD (depression-dejection) | 1.4 (0.7, 2.2) | 1.4 (0.7, 2.2) | 1.7 (1.0, 2.5) | 1.3 (0.6, 2.0) | 1.5 (0.8, 2.2) | 1.2 (0.5, 2.0) | 0.12 | 0.89 | 0.34 | 0.57 | 0.87 | 0.44 |
| AROUSAL (arousal) | 15.7 (13.5, 17.9) | 15.1 (12.9, 17.4) | 17.1 (15.0, 19.3) | 13.3 (11.1, 15.5) | 15.2 (13.0, 17.4) | 12.4* (10.2, 14.5) | 0.31 | 0.73 | 11.26 | 0.001 | 4.25 | 0.018 |
| TMD (total mood disturbance) | −5.1 (−8.8, −1.4) | −1.6 (−5.3, 2.2) | −1.4 (−5.1, 2.3) | −2.7 (−6.4, 1.0) | −2.8 (−6.5, 0.8) | 0.4 (−3.3, 4.0) | 3.96 | 0.02 | 0.87 | 0.35 | 1.38 | 0.26 |
| GRS | 0.1 (−0.1, 0.4) | 0.7 (0.5, 1.0) | 1.0 (0.7, 1.2) | 0.1 (−0.2, 0.3) | 0.7 (0.5, 0.9) | 0.9 (0.7, 1.2) | 47.88 | 0.0000 | 0.12 | 0.73 | 0.02 | 0.98 |
Abbreviations: ANOVA, analysis of variance; ARCI, Addiction Research Center Inventory; POMS, Profile of Mood States; GRS, Global Rating of Stimulation.
*
Topiramate was significantly different from placebo at the same cocaine dose.