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Endogenous pregnancy-associated plasma protein-A (PAPP-A) gene expression in wild-type mice (dashed line) and PAPP-A transgenic (Tg) mice (solid line) following unilateral carotid ligation. Mouse PAPP-A mRNA levels were measured by real-time PCR, and ligated values are expressed relative to the unligated (sham) artery. Results are means ± SE of 4–6 mice. There were no significant differences between WT and PAPP-A Tg mice.
