Table 1.
Neointimal hyperplasia following unilateral carotid ligation
| % Occlusion |
|||
|---|---|---|---|
| Postligation | WT | PAPP-A Tg′ | PAPP-A TgPD |
| Day 5 | 26 ± 4 (5) | 11 ± 3 (8)* | |
| Day 10 | 45 ± 10 (9) | 22 ± 3 (9)* | 36 ± 12 (9) |
| Day 15 | 72 ± 9 (9) | 38 ± 10 (6)* | |
Results are means ± SE, with nos. of mice in parentheses. WT, wild type; PAPP-A, pregnancy-associated plasma protein-A; Tg, transgenic; PAPP-A Tg′, different PAPP-A Tg founder (PAPP-A Tg6′ in 9 mice); PAPP-A TgPD, “protease-dead” PAPP-A Tg (mutation E483A). Unilateral carotid ligation was performed as described in materials and methods. %Occlusion was calculated as 100 minus [luminal area divided by internal elastic lamina].
*
P < 0.05 vs. WT.