Fig. 3.

Gallein and mSIRK modulate insulin release but do not alter cellular redox potential. A: percent insulin content released from intact islets after static incubation at low (LG, 2.8 mM) or high (HG, 16.7 mM) glucose in the presence and absence of gallein (10 μM, checkered) or mSIRK (30 μM, striped). Untreated control samples are shown in white. Data are means ± SE; n = 5–11. *P < 0.02, significance vs. untreated control. B: percent change in NAD(P)H, as a function of glucose, from untreated intact islets (black circles) and islets treated with gallein (10 μM, black squares) or mSIRK (30 μM, black triangles) vs. values at 2 mM glucose. Data are means ± SE; n = 4–11.