Fig. 1.

A: mean weight at 4, 8, and 12 mo of age; error bars show SE. Weights of animals at 4 wk (before treatment) are shown as solid black bars below the shaded weight gain bars and did not differ. At all ages, there was a complete separation of weight gain between groups, so that all repeated insulin-induced hypoglycemia (RH) animals were heavier than all control animals. There were significant effects of both age and treatment on weight gain, as well as an interaction between treatment and age: control animals' mean weight was significantly lower than that of RH animals at all ages (all P < 0.0001). B: median-weight animals from the control (top left) and RH (bottom right) groups are pictured at 8 mo to illustrate differences in body size.