Fig. 6.
KDITSN-1s induces mouse lung injury and alters pulmonary function tests. A Histology (H&E) of untreated (a1), siRNAITSN, 10d, (a2) and siRNAITSN, 24d, (a3) Bar 20 μm. B Morphometric analyses of MLI show no difference between the mice with chronic siRNAITSN (24d) and controls. 30 random high power fields were counted for each group. Data are shown as mean values ± SEM. *P < 0.05 (siRNAITSN 24d compared to siRNAITSN, 10d). C Pulmonary function tests—CL, IC and airway RL—measurements in KDITSN mouse. Lines within the boxes show medians; bounds of the boxes show 25th and the 75th percentiles of the data, respectively; the dark circles show outliers. All data are presented as mean ± SEM; P < 0.001. Results are representative for three different experiments, with 3–4 mice/experimental condition